Regions are rectangular, named areas within a house. Regions have configurable PvP + damage settings and have two action holders that will run when the player enters or exits the region. Regions can also be tested for within Conditionals.

Using the Region Selection Tool, left and right click can be used to set the positions of point A and B respectively. These two points define a rectangular prism by two opposite corners, also known as a selection region. To turn a Pro Tool selection region into a customizable Systems region, the Regions section of the Systems menu must be navigated to in order to use the Create Region functionality. Regions cannot be relocated once they have been created, but can be renamed.