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Regions are a system that allow players to specify areas in the world with custom settings. Regions have configurable PvP and damage settings. Each region has two action holders that can be triggered, one for entering the region and one for exiting the region. Regions can also be used in combination with conditional actions and placeholders.

Using the Region Selection Tool, the left and right mouse buttons can be used on a block to pick the selection's A and B position. These two points define a cube, often referred to as a selection region. To turn a Pro Tool selection into a region, you can either use the /region create command or navigate to Regions via the systems submenu.